Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression

Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the mechanistic contribution of host and tumor PD-L1 and PD-1 signaling to the therapeutic efficacy of PD-L1 and PD-1 blockade remains elusive....

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Published in:	The Journal of clinical investigation 2018-02, Vol.128 (2), p.805-815
Main Authors:	Lin, Heng, Wei, Shuang, Hurt, Elaine M., Green, Michael D., Zhao, Lili, Vatan, Linda, Szeliga, Wojciech, Herbst, Ronald, Harms, Paul W., Fecher, Leslie A., Vats, Pankaj, Chinnaiyan, Arul M., Lao, Christopher D., Lawrence, Theodore S., Wicha, Max, Hamanishi, Junzo, Mandai, Masaki, Kryczek, Ilona, Zou, Weiping
Format:	Article
Language:	English
Subjects:	Animal models Animals Apoptosis B7 antigen B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - metabolism Biomedical research Cancer regression Cancer therapies Cell death Cell Line, Tumor CTLA-4 protein Cytokines - metabolism Dendrites - metabolism Dendritic cells Dendritic Cells - metabolism Endometrial Neoplasms - drug therapy Endometrial Neoplasms - pathology Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Homeodomain Proteins - genetics Humans Immune system Immunodeficiency Ligands (Biochemistry) Liver cancer Lung cancer Lymph nodes Lymph Nodes - pathology Lymphatic system Lymphocytes Macrophages Macrophages - metabolism Male Melanoma Melanoma - drug therapy Melanoma - pathology Melanoma, Experimental Mice Mice, Inbred C57BL Mice, SCID Microenvironments Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology PD-1 protein PD-L1 protein Rodents Skin Neoplasms - drug therapy Skin Neoplasms - pathology Time Factors Tumor cells Tumor Microenvironment Tumors
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