THIOL-BASED REGULATORY SWITCHES

Thiol-based regulatory switches play central roles in cellular responses to oxidative stress, nitrosative stress, and changes in the overall thiol-disulfide redox balance. Protein sulfhydryls offer a great deal of flexibility in the different types of modification they can undergo and the range of c...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of genetics 2003, Vol.37 (1), p.91-121
Main Authors: Paget, Mark S.B, Buttner, Mark J
Format: Article
Language:English
Subjects:
Animals
Cells
Cellular control mechanisms
Chemicals
cysteine
disulfide bonds
Genetic aspects
Genetics
Homeostasis - physiology
Humans
metal coordination
OhrR protein
Oxidation
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
OxyR protein
Proteins
redox reactions
Sulfhydryl Compounds - physiology
Thiols
transcriptional regulation
Zinc - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thiol-based regulatory switches play central roles in cellular responses to oxidative stress, nitrosative stress, and changes in the overall thiol-disulfide redox balance. Protein sulfhydryls offer a great deal of flexibility in the different types of modification they can undergo and the range of chemical signals they can perceive. For example, recent work on OhrR and OxyR has clearly established that disulfide bonds are not the only cysteine oxidation products that are likely to be relevant to redox sensing in vivo. Furthermore, different stresses can result in distinct modifications to the same protein; in OxyR it seems that distinct modifications can occur at the same cysteine, and in Yap1 a partner protein ensures that the disulfide bond induced by peroxide stress is different from the disulfide bond induced by other stresses. These kinds of discoveries have also led to the intriguing suggestion that different modifications to the same protein can create multiple activation states and thus deliver discrete regulatory outcomes. In this review, we highlight these issues, focusing on seven well-characterized microbial proteins controlled by thiol-based switches, each of which exhibits unique regulatory features.
ISSN:0066-4197
1545-2948
DOI:10.1146/annurev.genet.37.110801.142538