Synthesis of 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] via two coupled one-pot processes Ugi-azide/Pictet–Spengler and oxidative spiro-rearrangement

Six novel tris-heterocycles 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] were synthesized in 39–82% yields in two experimental steps: (i) a one-pot Ugi-azide/Pictet–Spengler process coupled to (ii) a one-pot oxidative spiro-rearrangement. The synthesized polyheterocycles could be used for f...

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Bibliographic Details
Published in:New journal of chemistry 2018, Vol.42 (3), p.1600-1603
Main Authors: Alvarez-Rodríguez, Nancy V., Islas-Jácome, Alejandro, Rentería-Gómez, Angel, Cárdenas-Galindo, Luis E., Unnamatla, M. V. Basavanag, Gámez-Montaño, Rocío
Format: Article
Language:English
Subjects:
Synthesis
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Summary:Six novel tris-heterocycles 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] were synthesized in 39–82% yields in two experimental steps: (i) a one-pot Ugi-azide/Pictet–Spengler process coupled to (ii) a one-pot oxidative spiro-rearrangement. The synthesized polyheterocycles could be used for further in vitro studies because they contain moieties present in various anticancer bioactive molecules and drugs.
ISSN:1144-0546
1369-9261
DOI:10.1039/C7NJ03829A