Occupations and Lung Cancer: A Population-Based Case-Control Study in British Columbia

An investigation based on a large population-based case-control study in British Columbia, Canada, was conducted to identify high-risk occupations for lung cancer by histological subtypes. Subjects were 14,755 male incident cancer cases for whom lifetime occupational histories and information on smo...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2009-01, Vol.72 (10), p.658-675
Main Authors: Yenugadhati, Nagarajkumar, Birkett, Nicholas J., Momoli, Franco, Krewski, Daniel
Format: Article
Language:English
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Summary:An investigation based on a large population-based case-control study in British Columbia, Canada, was conducted to identify high-risk occupations for lung cancer by histological subtypes. Subjects were 14,755 male incident cancer cases for whom lifetime occupational histories and information on smoking and relevant covariates were collected. Occupational associations for 2998 lung cancer cases, including histological subtypes, were assessed by logistic regression using other cancer cases, excluding smoking-related cancers, as controls. An excess risk of lung cancer was found among workers in metal processing, bakers, and ship deck crew for all histological subtypes, and construction workers, chefs and cooks, and medical workers for specific histological subtypes. Occupational associations that are unique to histological subtypes of lung cancer were identified. Owing to a scarcity of literature in this area, future research needs to focus on confirming these histological associations, and identifying the risk from key exposures found within these occupations (e.g., medical radiation, electromagnetic fields, and cooking fumes).
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287390802476892