GLD2 poly(A) polymerase is required for long-term memory

The formation of long-term memory is believed to require translational control of localized mRNAs. In mammals, dendritic mRNAs are maintained in a repressed state and are activated upon repetitive stimulation. Several regulatory proteins required for translational control in early development are th...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (38), p.14644-14649
Main Authors: Kwak, Jae Eun, Drier, Eric, Barbee, Scott A, Ramaswami, Mani, Yin, Jerry C.P, Wickens, Marvin
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Antibodies
Biological Sciences
Brain
Cells, Cultured
Cytoplasm - enzymology
Drosophila
Drosophila melanogaster - enzymology
Drosophila Proteins - metabolism
Enzymes
Fragile X Mental Retardation Protein - metabolism
Insects
Memory
Memory - physiology
Messenger RNA
Motor Neurons - enzymology
Neurites - enzymology
Neurons
Polyadenylation
Polynucleotide Adenylyltransferase - metabolism
Proteins
Ribonucleic acid
RNA
RNA polymerase
RNA-Binding Proteins - metabolism
Training
Transcription Factors - metabolism
Transgenes
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Summary:The formation of long-term memory is believed to require translational control of localized mRNAs. In mammals, dendritic mRNAs are maintained in a repressed state and are activated upon repetitive stimulation. Several regulatory proteins required for translational control in early development are thought to be required for memory formation, suggesting similar molecular mechanisms. Here, using Drosophila, we identify the enzyme responsible for poly(A) elongation in the brain and demonstrate that its activity is required specifically for long-term memory. These findings provide strong evidence that cytoplasmic polyadenylation is critical for memory formation, and that GLD2 is the enzyme responsible.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0803185105