Cobalt-catalyzed asymmetric reactions of heterobicyclic alkenes with in situ generated organozinc halides

A general strategy for the asymmetric allylation and benzylation of heterobicyclic alkenes is described by employing in situ generated organozinc halides. This methodology features the application of a co-catalytic system comprising chiral cobalt complex and Lewis acid, which deliver both the asymme...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2018-04, Vol.5 (7), p.1108-1112
Main Authors: Li, Yun, Chen, Jingchao, He, Zhenxiu, Qin, Hongyu, Zhou, Yongyun, Khan, Ruhima, Fan, Baomin
Format: Article
Language:English
Subjects:
Alkenes
Allyl compounds
Asymmetry
Catalysis
Chemical reactions
Cobalt
Cobalt compounds
Halides
Lewis acid
Organic chemistry
Ring opening
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Summary:A general strategy for the asymmetric allylation and benzylation of heterobicyclic alkenes is described by employing in situ generated organozinc halides. This methodology features the application of a co-catalytic system comprising chiral cobalt complex and Lewis acid, which deliver both the asymmetric ring opening products of oxabenzonorbornadienes and the asymmetric addition products of azabenzonorbornadienes, respectively.
ISSN:2052-4110
2052-4110
DOI:10.1039/c7qo01064h