Hydrophobicity‐enhanced adhesion of novel biomimetic biocompatible polyaspartamide derivative glues

The development of wet bioadhesives for tissue fixation and wound care remains a challenge. While various commercial bioadhesive products based on both natural and synthetic materials are available, both types of adhesive have several drawbacks including weak adhesion or toxicity. In this study, we...

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Bibliographic Details
Published in:Polymer international 2018-05, Vol.67 (5), p.557-565
Main Authors: Wang, Bo, Lee, Jae Sang, Jeon, Young‐Sil, Kim, Jaeyun, Kim, Ji‐Heung
Format: Article
Language:English
Subjects:
Adhesion
Adhesive strength
Adhesives
Alkylamines
bioadhesive
Biocompatibility
Biomimetics
Calcium
Calcium ions
Crosslinking
Deionization
Dopamine
Glass substrates
Glues
Hydrophobicity
Magnesium
Metal ions
Metals
Plastics
polyaspartamide
Polymers
Toxicity
Wounds
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Summary:The development of wet bioadhesives for tissue fixation and wound care remains a challenge. While various commercial bioadhesive products based on both natural and synthetic materials are available, both types of adhesive have several drawbacks including weak adhesion or toxicity. In this study, we present a novel mussel‐inspired synthetic adhesive based on polyaspartamide derivatives modified with dopamine and a series of hydrophobic n‐alkylamines (lauryl, octyl, hexyl and butyl), which shows very strong adhesion toward various types of substrates such as paper, glass and metals as well as several common plastics (0.1–0.6 MPa). Additionally, the effect of adding metal ions (Mg2+, Ca2+) as a coordination crosslinker to enhance adhesion performance was investigated using acryl plastic substrate. Even under deionized water conditions, the strong adhesion was found to be maintained for an appreciably long time after 24 h. This novel and biocompatible polymer glue system has potential in various applications including as a medical tissue adhesive and sealant. © 2018 Society of Chemical Industry We present a novel mussel‐inspired synthetic adhesive based on polyaspartamide derivatives modified by dopamine and a series of hydrophobic n‐alkylamines (lauryl, octyl, hexyl, butyl). The resulting polymeric glues showed strong adhesion towards various types of substrates. In addition, as the chain length of the alkyl pendant was increased, the adhesion strength tended to increase, suggesting the hydrophobic environment enhanced the adhesive strength at the adhesion interface. The novel and biocompatible adhesive has potential for use in a variety of industrial and biomedical applications.
ISSN:0959-8103
1097-0126
DOI:10.1002/pi.5544