Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG)

• Published in: International journal of clinical oncology 2018-10, Vol.23 (5), p.965-973
• Main Authors: Hishiki, Tomoro, Matsumoto, Kimikazu, Ohira, Miki, Kamijo, Takehiko, Shichino, Hiroyuki, Kuroda, Tatsuo, Yoneda, Akihiro, Soejima, Toshinori, Nakazawa, Atsuko, Takimoto, Tetsuya, Yokota, Isao, Teramukai, Satoshi, Takahashi, Hideto, Fukushima, Takashi, Kaneko, Takashi, Hara, Junichi, Kaneko, Michio, Ikeda, Hitoshi, Tajiri, Tatsuro, Nakagawara, Akira
• Format: Article
• Language: English
• Subjects: Adolescent; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers, Tumor - genetics; Cancer; Cancer Research; Carboplatin; Carboplatin - administration & dosage; Chemotherapy; Child; Child, Preschool; Children; Comparative Genomic Hybridization; Etoposide; Etoposide - administration & dosage; Female; Hematopoietic stem cells; Humans; Induction Chemotherapy; Infant; Japan; Male; Medical prognosis; Medicine; Medicine & Public Health; Melphalan; Melphalan - administration & dosage; Metastases; Neuroblastoma; Neuroblastoma - drug therapy; Neuroblastoma - genetics; Neuroblastoma - pathology; Oncology; Original Article; Patients; Prospective Studies; Radiation therapy; Stem cells; Surgery; Surgical Oncology; Survival Rate; Toxicity; Treatment Outcome
• ISSN: 1341-9625; 1437-7772
• DOI: 10.1007/s10147-018-1281-8

Background The Japanese Children’s Cancer Group (JCCG) Neuroblastoma Committee (JNBSG) conducted a phase II clinical trial for high-risk neuroblastoma treatment. We report the result of the protocol treatment and associated genomic aberration studies. Methods JN-H-07 was a single-arm, late phase II trial for high-risk neuroblastoma treatment with open enrollment from June 2007 to February 2009. Eligible patients underwent five courses of induction chemotherapy followed by high-dose chemotherapy with hematopoietic stem cell rescue. Surgery for the primary tumor was scheduled after three or four courses of induction chemotherapy. Radiotherapy was administered to the primary tumor site and to any bone metastases present at the end of induction chemotherapy. Results The estimated 3-year progression-free and overall survival rates of the 50 patients enrolled were 36.5 ± 7.0 and 69.5 ± 6.6%, respectively. High-dose chemotherapy caused severe toxicity including three treatment-related deaths. In response to this, the high-dose chemotherapy regimen was modified during the trial by infusing melphalan before administering carboplatin and etoposide. The modified high-dose chemotherapy regimen was less toxic. Univariate analysis revealed that patients younger than 547 days and patients whose tumor showed a whole chromosomal gains / losses pattern had a significantly poor prognosis. Notably, the progression-free survival of cases with MYCN amplification were not inferior to those without MYCN amplification. Conclusions The outcome of patients treated with the JN-H-07 protocol showed improvement over the results reported by previous studies conducted in Japan. Molecular and genetic profiling may enable a more precise stratification of the high-risk cohort.