Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation[S]

In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content...

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Bibliographic Details
Published in:Journal of lipid research 2018, Vol.59 (5), p.784-794
Main Authors: Kotzbeck, Petra, Giordano, Antonio, Mondini, Eleonora, Murano, Incoronata, Severi, Ilenia, Venema, Wiebe, Cecchini, Maria Paola, Kershaw, Erin E., Barbatelli, Giorgio, Haemmerle, Guenter, Zechner, Rudolf, Cinti, Saverio
Format: Article
Language:English
Subjects:
adipocyte size
Adipocytes
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - metabolism
Adipose Tissue, Brown - pathology
Adipose Tissue, White - metabolism
Adipose Tissue, White - pathology
adipose triglyceride lipase
Animals
brown fat
Cell Death
Cholesterol
Collagen
Crystals
Death
Endoplasmic reticulum
Fibrils
Gene expression
Inflammasomes
Inflammation
Inflammation - metabolism
Inflammation - pathology
Lipase
Lipase - deficiency
Lipase - metabolism
Lipids
macrophage
Macrophages
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
nucleotide-binding oligomerization domain-like receptor-3 inflammasome
Obesity
Rodents
Thermogenesis
Transmission electron microscopy
white adipocyte
white adipose tissue
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