0459 Cardiovascular Dysfunctions Associated with Sleep-related Breathing Disturbances

Abstract Introduction Convincing evidence emphasizes cardiac arrhythmias and sleep-disordered breathing (SDB) as independent risk factors for stroke and cardiovascular mortality. Sleep research focused on acute cardiac events following respiratory disturbances (ACERD) may provide deeper insights int...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2018-04, Vol.41 (suppl_1), p.A173-A174
Main Authors: Palamarchuk, I S, Saad, M, Douglass, A B, Lee, E, Ray, L, BuJaki, B, Parvaresh, A, De Koninck, J, Robillard, R
Format: Article
Language:English
Subjects:
NREM sleep
REM sleep
Sleep apnea
Sleep deprivation
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Summary:Abstract Introduction Convincing evidence emphasizes cardiac arrhythmias and sleep-disordered breathing (SDB) as independent risk factors for stroke and cardiovascular mortality. Sleep research focused on acute cardiac events following respiratory disturbances (ACERD) may provide deeper insights into the link between nocturnal cardiovascular deterioration and central dysautonomia. We aimed to investigate ACERD occurrence across sleep stages in people with various degrees of SDB. Methods Clinical polysomnography for 221 individuals with sleep complaints referred to a sleep clinic was analyzed to identify the co-occurrence of ACERD within hazard period of 90 seconds. Beside the apnea hypopnea index (AHI), a respiratory-cardiac index (RCI) was calculated as the total count of respiratory-to-cardiac events occurring during specific sleep stage divided by the number of minutes spent in the sleep stage. Results People with low SDB (AHI
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsy061.458