Findings on 3D speckle tracking echocardiography in asymptomatic methamphetamine abusers

• Published in: The International Journal of Cardiovascular Imaging 2018-10, Vol.34 (10), p.1589-1593
• Main Authors: Zhang, Li-Juan, Chen, Ke-Qi, Shi, Yun-Yan, Qiao, Xiao-Ling, Wang, Lian-You, Zheng, Xiao-Zhi
• Format: Article
• Language: English
• Subjects: Abnormalities; Adolescent; Adult; Amphetamine-Related Disorders - complications; Cardiac Imaging; Cardiology; Cardiotoxicity; Central Nervous System Stimulants - adverse effects; Drug abuse; Echocardiography; Echocardiography, Three-Dimensional; Heart; Heart diseases; Humans; Imaging; Male; Medicine; Medicine & Public Health; Methamphetamine; Methamphetamine - adverse effects; Original Paper; Radiology; Three dimensional flow; Tracking; Velocity; Ventricle; Ventricular Dysfunction, Left - chemically induced; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left - drug effects; Ventricular Function, Left - physiology; Young Adult
• ISSN: 1569-5794; 1573-0743; 1875-8312
• DOI: 10.1007/s10554-018-1381-6

To detect potential cardiac abnormalities in asymptomatic methamphetamine abusers using three-dimensional speckle tracking echocardiography (3D STE). Fifty-three male methamphetamine abusers, free of cardiac symptoms/signs, were enrolled in this study. A control group of 53 age-matched male normal subjects was studied for comparison. Standard 3D, flow and tissue Doppler echo with measurements of left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), ejection fraction (LVEF), the ratio of the early to late diastolic transmitral filling velocity (E/A), the ratio of the early diastolic transmitral filling velocity to the early diastolic septal tissue velocity (E/E′) and 3D STE with measurements of global area strain (GAS), global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS) were performed, respectively. These echocardiographic parameters were compared between methamphetamine abusers and normal subjects, and receiver operating characteristic curve (ROC) analysis was done to differentiating methamphetamine abusers from normal subjects. LVESV, LVEDV, LVEF, E/A, E/E′ ratios and GRS were not significantly different between methamphetamine abusers and normal subjects ( p  > 0.05). However, GAS, GLS and GCS were significantly less in methamphetamine abusers than in normal subjects ( p