Rivastigmine Tartrate Solid Lipid Nanoparticles Loaded Transdermal Film: An In vivo study

The advantages of transdermal drug delivery is, providing controlled release of the drug to the patient and enabling a steady blood level profile, avoidance of first-pass hepatic metabolism and helping in the rapid termination of therapy11. After 3 minutes the first film was removed and if no seriou...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018, Vol.11 (1), p.227-227
Main Authors: Ravi, G, Gupta, Vishal N, Balamuralidhara, V
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal cognition
Computer simulation
Corrosion
Dementia
Drug delivery systems
Experiments
Geriatrics
Lipids
Nanoparticles
Organic chemicals
Pharmaceutical sciences
Pharmacy
Rabbits
Studies
Toxicology
Transdermal medication
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Summary:The advantages of transdermal drug delivery is, providing controlled release of the drug to the patient and enabling a steady blood level profile, avoidance of first-pass hepatic metabolism and helping in the rapid termination of therapy11. After 3 minutes the first film was removed and if no serious skin reaction was observed, then a second film was applied at a different site and removed after 1 h and the observations at this stage indicated that exposure can humanely be allowed to extend to four hours, a third film was applied and removed after 4 h, and Dermal toxicity was scored and recorded according to the Draize scoring system (Table 1) If a corrosive effect was observed after any of the three sequential exposures, the test was immediately terminated. Aqil M, Ali A. Monolithic matrix type transdermal drug delivery systems of pinacidil monohydrate: in vitro characterisation. Development of validated RP-HPLC method for quantitative estimation of Rivastigmine hydrogen tartrate in transdermal drug delivery system.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2018.00042.2