Palladium‐Catalyzed Regioselective C‐2 Arylation of Benzofurans with N′‐Acyl Arylhydrazines

A novel ligand‐free palladium‐catalyzed C‐2 arylation of benzofurans has been developed using N′‐acyl arylhydrazines as the coupling partners and TEMPO as an oxidant. This protocol features a wide functional‐group tolerance and highly regioselective products with good to excellent yields. An efficie...

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Bibliographic Details
Published in:European journal of organic chemistry 2018-06, Vol.2018 (22), p.2774-2779
Main Authors: Cao, Jun, Chen, Zi‐Li, Li, Shu‐Min, Zhu, Gao‐Feng, Yang, Yuan‐Yong, Wang, Cong, Chen, Wen‐Zhang, Wang, Jian‐Ta, Zhang, Ji‐Quan, Tang, Lei
Format: Article
Language:English
Subjects:
Arylation
Arylhydrazines
Benzofurans
Palladium
Regioselectivity
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Summary:A novel ligand‐free palladium‐catalyzed C‐2 arylation of benzofurans has been developed using N′‐acyl arylhydrazines as the coupling partners and TEMPO as an oxidant. This protocol features a wide functional‐group tolerance and highly regioselective products with good to excellent yields. An efficient and ligand‐free palladium‐catalyzed arylation of benzofurans has been developed with N′‐acyl arylhydrazines as the coupling partners. This protocol features a wide functional‐group tolerance and highly regioselective products.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201800374