Evaluating the Impact of Sterilization on Gel Formulations

The goal was to achieve a decay of chemical degradation processes that occurred as a result of radiation. * Determination of the degradation behaviour of Lidocaine and Chlorhexidine using high-performance liquid chromatography (HPLC) methods. * HPLC-UV/Visible analysis. Before analysis, samples were...

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Bibliographic Details
Published in:Pharmaceutical technology Europe 2018-04, Vol.30 (4), p.23-26
Main Authors: Steiner-Reischütz, Nicole, Pyerin, Michael, Kanakaki, Chrysoula, Neubert, Daniela, Washüttl, Michael, Krainz, Michael
Format: Article
Language:English
Subjects:
Cellulose
Chromatography
Color
Good Manufacturing Practice
Ingredients
Pharmaceuticals
Radiation
Rheology
Sensors
Viscosity
VOCs
Volatile organic compounds
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Summary:The goal was to achieve a decay of chemical degradation processes that occurred as a result of radiation. * Determination of the degradation behaviour of Lidocaine and Chlorhexidine using high-performance liquid chromatography (HPLC) methods. * HPLC-UV/Visible analysis. Before analysis, samples were diluted 1:10 in 0.1 % trifluoro acetic acid in 20% ACN to 80% water. * Determination of volatile and semi-volatile substances by gas chromatography/mass spectroscopy (GC/MS). GC/FID/MS analysis, using liquid injection, was performed using a GC system (7890A GC, Agilent Technologies), coupled to a mass selective detector (5975C inert XL MSD with a ZW-WAX Plus, Agilent Technologies) at 250 °C. A 30-m x 250-pm x 0.5-pm capillary column was used, with helium as the carrier gas. [...]most decomposition products are not detectable under the conditions specified by HPLC -UV/VIS and, therefore, will not be visible in the mass balance.
ISSN:1753-7967