Transfer hydrogenation of ketones catalyzed by iridium-bulky phosphine complexes

• Published in: Inorganica Chimica Acta 2018-01, Vol.470, p.303-311
• Main Authors: Landaeta, Vanessa R., Rosa, Abel D. Salazar-La, Rodríguez-Lugo, Rafael E.
• Format: Article
• Language: English
• Subjects: Alcohol; Aliphatic compounds; Bulky phosphines; Carbonyl groups; Carbonyls; Catalysis; Conversion; Dependence; Hydrogen; Hydrogen source; Hydrogen storage; Hydrogenation; Ir(I) complexes; Iridium; Isopropanol; Ketones; Molecular chains; Molecules; Steric hindrance; Substrates; Transfer hydrogenation
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2017.08.014

[Display omitted] •Ir-catalyzed transfer hydrogenation of ketones from isopropyl alcohol was studied.•The mixed phosphine complex [Ir(COD)(PBn3)(PAn3)]PF6 was the most active precursor.•12 examples of ketones with different stereo-electronic properties were reduced.•A pseudo first-order dependence of the reaction rate with [ketone] was determined.•In situ NMR tests and stoichiometric experiments shed light into the reaction pathway. The complexes [Ir(COD)(PR3)2]PF6 (R=PPh3 (1); R=PBn3=tribenzylphosphine (2)), [Ir(COD)(PBn3)(PAn3)]PF6 (3) (PAn3=Tri-orthoanisyl-phosphine) and cis-(P,P)-[IrH(COD)(PBn3){η2-P,C-(C6H4CH2)PBn2}]PF6 (4) are active in the transfer hydrogenation of ketones. However, complex (3) gives the best results in conversion toward the alcohol. Interestingly, commercial isopropanol was used as hydrogen source, without any drying treatment. In situ generated isopropoxide was used as base. An efficient conversion of a variety of ketones, aromatic or aliphatic, cyclic or linear, including molecules with conjugated or isolated CC moieties was achieved, thus reporting 12 examples of hydrogenated substrates. Ketones of higher steric hindrance could not be converted under the studied conditions. The experimental evidence indicates that the steric and electronic properties of the substrates are determinant in the observed conversions and performance of the system. For α,β-unsaturated ketones, preference toward the reduction of the CC bond was observed. However, the system shows chemoselectivity toward the carbonyl group in molecules which also bear an isolated CC moiety. With the results obtained, a pseudo first-order dependence of the reaction rate on the concentration of ketone was determined. Also, stoichiometric as well as in situ tests were performed to shed light into the reaction pathways possibly involved in the catalytic TH of ketones described herein (precursor 3, base and isopropyl alcohol as hydrogen source).