INTRA-INDIVIDUAL DIFFERENCES IN PLASMA FERRITIN CONCENTRATION IN RELATION TO INFLAMMATION OBSERVED DURING A SHORTTERM LONGITUDINAL STUDY ARE SIMILAR TO CROSS-SECTIONAL INTER-INDIVIDUAL DIFFERENCES

Background and objectives: Cross-sectional (CS) surveys indicate that individuals with acute inflammation have higher plasma ferritin (pF) concentrations than those without, possibly due to either inflammation-induced increases in pF or a heightened risk of inflammation among individuals with higher...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 2017-10, Vol.71 (Suppl. 2), p.1145
Main Authors: Wessells, K Ryan, Peerson, Janet M, Hess, Sonja, Rouamba, Noel, Ouédraogo, Jean Bosco, Brown, Ken
Format: Article
Language:English
Subjects:
Alpha iron
C-reactive protein
Children
Children & youth
Correlation analysis
Cross-sections
Data collection
Ferritin
Glycoproteins
Iron
Longitudinal studies
Nutrient deficiency
Plasma
Polls & surveys
Population studies
Proteins
Regression analysis
Regression models
Vitamin deficiency
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Summary:Background and objectives: Cross-sectional (CS) surveys indicate that individuals with acute inflammation have higher plasma ferritin (pF) concentrations than those without, possibly due to either inflammation-induced increases in pF or a heightened risk of inflammation among individuals with higher iron status. To determine the validity of adjusting pF for inflammation using CS data, we assessed the effects of short-term changes in inflammation status on pF, based on the assumption that body iron stores were unlikely to change during the study period. Methods: Two blood samples were obtained 21d apart from 451 asymptomatic 6-23mo Burkinabe children; plasma was analyzed for ferritin, C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP). Inflammation was defined as CRP>5mg/L and/or AGP>1g/L. Additionally, a regression correction (RC) approach was used to adjust pF to a presumably healthy reference point within the study population (10th percentile CRP/AGP concentrations). Cross-sectional RCs were estimated from a naive regression model which treated observations from the same children as independent. Longitudinal RCs, to estimate effects of intra-individual changes in CRP/AGP were estimated from structural equation models, accounting for repeated measures. Results: pF was significantly greater in children with inflammation (44.9±2.9μg/L) than those without (13.6±1.0μg/L; P
ISSN:0250-6807
1421-9697
DOI:10.1159/000480486