PLASMA VITAMIN C AND THE RISK OF GASTRIC CANCER RISK IN THE EURGAST STUDY

Background and objectives: Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are lim...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nutrition and metabolism 2017-10, Vol.71 (Suppl. 2), p.748
Main Authors: Jakszyn, Paula, Lujan, Leila, Aranda, Nuria, Sarrats, Ariadna, Agudo, Antonio
Format: Article
Language:English
Subjects:
Alcohols
Antioxidants
Ascorbic acid
Biomarkers
Cancer
Carcinogens
Case studies
Citrus fruits
Cohort analysis
Gastric cancer
Health risks
Helicobacter pylori
Liquid chromatography
Localization
Mass spectrometry
Mass spectroscopy
Meat
Nutrition
Regression analysis
Regression models
Risk
Risk assessment
Smoke
Stomach
Vitamin C
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and objectives: Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are limited. Recently the WCRF have included citrus fruit as a protective factor with limited-suggestive evidence specifically for gastric cardia cancers. Our previous analysis based on 256 cases and using a fluorometric method has an inverse association between GC and serum vitamin C .The objective of this study was to re-assess the association of plasma vitamin C levels with the risk of GC in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) including a larger sample size and a more accurate methodology. Methods: Serum vitamin C was measured using liquid chromatography coupled to mass spectrometry in 456 GC cases and 456 matched controls ( sex, age and blood collection ) form teh nested case control study EURGAST . Conditional logistic regression models adjusted smoke, education, BMI, helicobacter pylori infection , red meat, processed meat, alcohol, and energys were used to estimate relative cancer risks . Results: After adjusting by potential counfounders , No association with plasma vitamin C and gastric cancer risk was found (HR 20 microg/l: 0.947, 95 CI: 0.82-1.08 ). When results were analyzed by tumor localization, comparing highest vs. lowest tertiles of serum vitamin C results have shown a negative association for cardia cancer site ( HR 0.482, 95 % CI: 0.235- 0.99). No association was found for non cardia site. Conclusions: Plasma vitamin C levels may play a role decreasing the risk of cardia gastric cancer . More prospective studies, including a larger number of cardia cancers are needed to confirm these findings.
ISSN:0250-6807
1421-9697
DOI:10.1159/000480486