Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems....

Full description

Saved in:
Bibliographic Details
Published in:Development and psychopathology 2018-08, Vol.30 (3), p.1145-1156
Main Authors: Barker, Edward D., Cecil, Charlotte A. M., Walton, Esther, Houtepen, Lotte C., O'Connor, Thomas G., Danese, Andrea, Jaffee, Sara R., Jensen, Sarah K. G., Pariante, Carmine, McArdle, Wendy, Gaunt, Tom R., Relton, Caroline L., Roberts, Susanna
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Adolescents
Age
Brain research
Child
Child & adolescent mental health
Child Behavior Disorders - etiology
Child development
Cognitive ability
Cytokines
Deoxyribonucleic acid
DNA
DNA methylation
Epidemiology
Epigenetics
Female
Gene expression
Humans
Hypotheses
Immune system
Inflammation
Inflammation - complications
Laboratories
Male
Mental disorders
Mental Health
Mental health care
Pregnancy
Prospective Studies
Risk Factors
Special Issue Articles
Stress
Teenagers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c416t-670d341f02cf7759547f772fc87697c20af7d4800491b45ee1169ae1fb44b2c3
cites cdi_FETCH-LOGICAL-c416t-670d341f02cf7759547f772fc87697c20af7d4800491b45ee1169ae1fb44b2c3
container_end_page 1156
container_issue 3
container_start_page 1145
container_title Development and psychopathology
container_volume 30
creator Barker, Edward D.
Cecil, Charlotte A. M.
Walton, Esther
Houtepen, Lotte C.
O'Connor, Thomas G.
Danese, Andrea
Jaffee, Sara R.
Jensen, Sarah K. G.
Pariante, Carmine
McArdle, Wendy
Gaunt, Tom R.
Relton, Caroline L.
Roberts, Susanna
description In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7–15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7–15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.
doi_str_mv 10.1017/S0954579418000330
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2081315861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0954579418000330</cupid><sourcerecordid>2081315861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-670d341f02cf7759547f772fc87697c20af7d4800491b45ee1169ae1fb44b2c3</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EouXxAWyQJdYBT-LECTtU8ZIqsYB95Njj1pBHsV2kfgD_jUsLXSA2MyPPnTOeS8gZsEtgIK6eWZXzXFQcSsZYlrE9MgZeVEkKVblPxut2su6PyJH3r1GTZzw_JKOMsaLkrByTz8fetLLrZLBDnzhsZUBNcWFn2GOwijrr36jsNVVz2-rvSuqhRa-wD7SLQbZ0jrIN82t6Qxdu8AtUwX4g9WGpV9S4oYvPOOtlr1Y0DLSzWre4wyg8IQdGth5Pt_mYvNzdvkwekunT_ePkZpooDkVICsF0xsGwVBkh8nidiDk1qhRFJVTKpBGaRy94BQ3PEQGKSiKYhvMmVdkxudhg4y_fl-hD_TosXR831ikrIYO8LCCqYKNS8Rbv0NQLZzvpVjWweu17_cf3OHO-JS-bDvXvxI_RUZBtobJrnNUz3O3-H_sFfFmODQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2081315861</pqid></control><display><type>article</type><title>Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence</title><source>Criminology Collection</source><source>Social Science Premium Collection</source><source>Cambridge University Press</source><creator>Barker, Edward D. ; Cecil, Charlotte A. M. ; Walton, Esther ; Houtepen, Lotte C. ; O'Connor, Thomas G. ; Danese, Andrea ; Jaffee, Sara R. ; Jensen, Sarah K. G. ; Pariante, Carmine ; McArdle, Wendy ; Gaunt, Tom R. ; Relton, Caroline L. ; Roberts, Susanna</creator><creatorcontrib>Barker, Edward D. ; Cecil, Charlotte A. M. ; Walton, Esther ; Houtepen, Lotte C. ; O'Connor, Thomas G. ; Danese, Andrea ; Jaffee, Sara R. ; Jensen, Sarah K. G. ; Pariante, Carmine ; McArdle, Wendy ; Gaunt, Tom R. ; Relton, Caroline L. ; Roberts, Susanna</creatorcontrib><description>In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7–15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7–15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.</description><identifier>ISSN: 0954-5794</identifier><identifier>EISSN: 1469-2198</identifier><identifier>DOI: 10.1017/S0954579418000330</identifier><identifier>PMID: 30068408</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Adolescence ; Adolescent ; Adolescents ; Age ; Brain research ; Child ; Child &amp; adolescent mental health ; Child Behavior Disorders - etiology ; Child development ; Cognitive ability ; Cytokines ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Epidemiology ; Epigenetics ; Female ; Gene expression ; Humans ; Hypotheses ; Immune system ; Inflammation ; Inflammation - complications ; Laboratories ; Male ; Mental disorders ; Mental Health ; Mental health care ; Pregnancy ; Prospective Studies ; Risk Factors ; Special Issue Articles ; Stress ; Teenagers</subject><ispartof>Development and psychopathology, 2018-08, Vol.30 (3), p.1145-1156</ispartof><rights>Copyright © Cambridge University Press 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-670d341f02cf7759547f772fc87697c20af7d4800491b45ee1169ae1fb44b2c3</citedby><cites>FETCH-LOGICAL-c416t-670d341f02cf7759547f772fc87697c20af7d4800491b45ee1169ae1fb44b2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2081315861/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2081315861?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21376,21394,27924,27925,33611,33769,43733,43814,72960,74221,74310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30068408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barker, Edward D.</creatorcontrib><creatorcontrib>Cecil, Charlotte A. M.</creatorcontrib><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Houtepen, Lotte C.</creatorcontrib><creatorcontrib>O'Connor, Thomas G.</creatorcontrib><creatorcontrib>Danese, Andrea</creatorcontrib><creatorcontrib>Jaffee, Sara R.</creatorcontrib><creatorcontrib>Jensen, Sarah K. G.</creatorcontrib><creatorcontrib>Pariante, Carmine</creatorcontrib><creatorcontrib>McArdle, Wendy</creatorcontrib><creatorcontrib>Gaunt, Tom R.</creatorcontrib><creatorcontrib>Relton, Caroline L.</creatorcontrib><creatorcontrib>Roberts, Susanna</creatorcontrib><title>Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence</title><title>Development and psychopathology</title><addtitle>Dev Psychopathol</addtitle><description>In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7–15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7–15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Age</subject><subject>Brain research</subject><subject>Child</subject><subject>Child &amp; adolescent mental health</subject><subject>Child Behavior Disorders - etiology</subject><subject>Child development</subject><subject>Cognitive ability</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Epidemiology</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Laboratories</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Mental Health</subject><subject>Mental health care</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Special Issue Articles</subject><subject>Stress</subject><subject>Teenagers</subject><issn>0954-5794</issn><issn>1469-2198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>BGRYB</sourceid><sourceid>M0O</sourceid><recordid>eNp1kMtOwzAQRS0EouXxAWyQJdYBT-LECTtU8ZIqsYB95Njj1pBHsV2kfgD_jUsLXSA2MyPPnTOeS8gZsEtgIK6eWZXzXFQcSsZYlrE9MgZeVEkKVblPxut2su6PyJH3r1GTZzw_JKOMsaLkrByTz8fetLLrZLBDnzhsZUBNcWFn2GOwijrr36jsNVVz2-rvSuqhRa-wD7SLQbZ0jrIN82t6Qxdu8AtUwX4g9WGpV9S4oYvPOOtlr1Y0DLSzWre4wyg8IQdGth5Pt_mYvNzdvkwekunT_ePkZpooDkVICsF0xsGwVBkh8nidiDk1qhRFJVTKpBGaRy94BQ3PEQGKSiKYhvMmVdkxudhg4y_fl-hD_TosXR831ikrIYO8LCCqYKNS8Rbv0NQLZzvpVjWweu17_cf3OHO-JS-bDvXvxI_RUZBtobJrnNUz3O3-H_sFfFmODQ</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Barker, Edward D.</creator><creator>Cecil, Charlotte A. M.</creator><creator>Walton, Esther</creator><creator>Houtepen, Lotte C.</creator><creator>O'Connor, Thomas G.</creator><creator>Danese, Andrea</creator><creator>Jaffee, Sara R.</creator><creator>Jensen, Sarah K. G.</creator><creator>Pariante, Carmine</creator><creator>McArdle, Wendy</creator><creator>Gaunt, Tom R.</creator><creator>Relton, Caroline L.</creator><creator>Roberts, Susanna</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K7.</scope><scope>K9.</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>201808</creationdate><title>Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence</title><author>Barker, Edward D. ; Cecil, Charlotte A. M. ; Walton, Esther ; Houtepen, Lotte C. ; O'Connor, Thomas G. ; Danese, Andrea ; Jaffee, Sara R. ; Jensen, Sarah K. G. ; Pariante, Carmine ; McArdle, Wendy ; Gaunt, Tom R. ; Relton, Caroline L. ; Roberts, Susanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-670d341f02cf7759547f772fc87697c20af7d4800491b45ee1169ae1fb44b2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Age</topic><topic>Brain research</topic><topic>Child</topic><topic>Child &amp; adolescent mental health</topic><topic>Child Behavior Disorders - etiology</topic><topic>Child development</topic><topic>Cognitive ability</topic><topic>Cytokines</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Epidemiology</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Inflammation - complications</topic><topic>Laboratories</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Mental Health</topic><topic>Mental health care</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Special Issue Articles</topic><topic>Stress</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barker, Edward D.</creatorcontrib><creatorcontrib>Cecil, Charlotte A. M.</creatorcontrib><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Houtepen, Lotte C.</creatorcontrib><creatorcontrib>O'Connor, Thomas G.</creatorcontrib><creatorcontrib>Danese, Andrea</creatorcontrib><creatorcontrib>Jaffee, Sara R.</creatorcontrib><creatorcontrib>Jensen, Sarah K. G.</creatorcontrib><creatorcontrib>Pariante, Carmine</creatorcontrib><creatorcontrib>McArdle, Wendy</creatorcontrib><creatorcontrib>Gaunt, Tom R.</creatorcontrib><creatorcontrib>Relton, Caroline L.</creatorcontrib><creatorcontrib>Roberts, Susanna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Criminal Justice Periodicals</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology Journals</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Development and psychopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barker, Edward D.</au><au>Cecil, Charlotte A. M.</au><au>Walton, Esther</au><au>Houtepen, Lotte C.</au><au>O'Connor, Thomas G.</au><au>Danese, Andrea</au><au>Jaffee, Sara R.</au><au>Jensen, Sarah K. G.</au><au>Pariante, Carmine</au><au>McArdle, Wendy</au><au>Gaunt, Tom R.</au><au>Relton, Caroline L.</au><au>Roberts, Susanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence</atitle><jtitle>Development and psychopathology</jtitle><addtitle>Dev Psychopathol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>30</volume><issue>3</issue><spage>1145</spage><epage>1156</epage><pages>1145-1156</pages><issn>0954-5794</issn><eissn>1469-2198</eissn><abstract>In 785 mother–child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7–15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7–15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>30068408</pmid><doi>10.1017/S0954579418000330</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0954-5794
ispartof Development and psychopathology, 2018-08, Vol.30 (3), p.1145-1156
issn 0954-5794
1469-2198
language eng
recordid cdi_proquest_journals_2081315861
source Criminology Collection; Social Science Premium Collection; Cambridge University Press
subjects Adolescence
Adolescent
Adolescents
Age
Brain research
Child
Child & adolescent mental health
Child Behavior Disorders - etiology
Child development
Cognitive ability
Cytokines
Deoxyribonucleic acid
DNA
DNA methylation
Epidemiology
Epigenetics
Female
Gene expression
Humans
Hypotheses
Immune system
Inflammation
Inflammation - complications
Laboratories
Male
Mental disorders
Mental Health
Mental health care
Pregnancy
Prospective Studies
Risk Factors
Special Issue Articles
Stress
Teenagers
title Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T12%3A48%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inflammation-related%20epigenetic%20risk%20and%20child%20and%20adolescent%20mental%20health:%20A%20prospective%20study%20from%20pregnancy%20to%20middle%20adolescence&rft.jtitle=Development%20and%20psychopathology&rft.au=Barker,%20Edward%20D.&rft.date=2018-08&rft.volume=30&rft.issue=3&rft.spage=1145&rft.epage=1156&rft.pages=1145-1156&rft.issn=0954-5794&rft.eissn=1469-2198&rft_id=info:doi/10.1017/S0954579418000330&rft_dat=%3Cproquest_cross%3E2081315861%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c416t-670d341f02cf7759547f772fc87697c20af7d4800491b45ee1169ae1fb44b2c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2081315861&rft_id=info:pmid/30068408&rft_cupid=10_1017_S0954579418000330&rfr_iscdi=true