Development of Amoxicillin-Loaded Electrospun Polyurethane/Chitosan/[Formula Omitted]-Tricalcium Phosphate Scaffold for Bone Tissue Regeneration

Biocompatible nanocomposite electrospun fibers containing Polyurethane/Chitosan/[Formula Omitted]-Tri calcium phosphate with diverse concentrations were designed and produced through the electrospinning process for bone tissue engineering applications. After the production process, density measureme...

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Bibliographic Details
Published in:IEEE transactions on nanobioscience 2018-01, Vol.17 (3), p.321
Main Authors: Topsakal, Aysenur, Uzun, Muhammet, Ugar, Gaye, Ozcan, Aslihan, Altun, Esra, Faik Nuzhet Oktar, Fakhera Ikram, Ozkan, Ozan, Hilal Turkoglu Sasmazel, Gunduz, Oguzhan
Format: Magazinearticle
Language:English
Subjects:
Amoxicillin
Antibiotics
Biocompatibility
Bone growth
Bones
Calcium phosphates
Cell culture
Chitosan
Composition
Density measurement
Drug delivery systems
Electrical conductivity
Electrical resistivity
Electrospinning
Fibers
Fourier transforms
FTIR spectrometers
Infrared spectroscopy
Mechanical loading
Nanocomposites
Nanofibers
Organic chemistry
Polyurethane
Polyurethane resins
Regeneration
Scaffolds
Scanning electron microscopy
Structural analysis
Tissue engineering
Tricalcium phosphate
Viscosity
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Summary:Biocompatible nanocomposite electrospun fibers containing Polyurethane/Chitosan/[Formula Omitted]-Tri calcium phosphate with diverse concentrations were designed and produced through the electrospinning process for bone tissue engineering applications. After the production process, density measurement, viscosity, electrical conductivity, and tensile strength measurement tests were carried out as physical analyses of blended solutions. The chemical structural characterization was scrutinized using Fourier transform infrared spectrometer (FTIR), and scanning electron microscopy (SEM) was used to observe the morphological details of developed electrospun scaffolds. Cell viability, attachment, and proliferation were performed using a L929 fibroblast cell line. Based on the physical, SEM, FTIR analysis, and cell culture studies, preferable nanofiber composition was selected for further studies. Amoxicillin (AMX) was loaded to that selected nanofiber composition for examination of the drug release. In comparison with other studies on similar AMX controlled products, higher drug loading and encapsulation efficiencies were obtained. It has been clearly found that the developed nanofiber composites have potential for bone tissue engineering applications.
ISSN:1536-1241
1558-2639
DOI:10.1109/TNB.2018.2844870