Prevalence of Urinary Tract Infection, Microbial Aetiology, and Antibiotic Sensitivity Pattern among Antenatal Women Presenting with Lower Abdominal Pains at Kenyatta National Hospital, Nairobi, Kenya

• Published in: Open access journal of science and technology 2015, Vol.3
• Main Authors: Willy Fred, Nabbugodi, Gichuhi, J. Wanyoike, Mugo, N. W.
• Format: Article
• Language: English
• Subjects: Abdomen; Ampicillin; Antibiotics; Bacteria; Bacterial infections; Ceftazidime; Ceftriaxone; Cefuroxime; Citrobacter; Developing countries; E coli; Gentamicin; Gram-negative bacteria; Gram-positive bacteria; Hospitals; Imipenem; Klebsiella; Laboratories; LDCs; Levofloxacin; Medical research; Meropenem; Microorganisms; Microscopy; Nitrofurantoin; Pain; Pregnancy; Sensitivity; Sickle cell disease; Socioeconomic factors; Studies; Urinary tract; Urinary tract diseases; Urinary tract infections; Urine; Urogenital system; Womens health
• ISSN: 2314-5234; 2314-5234
• DOI: 10.11131/2015/101115

Objective. To determine the prevalence of urinary tract infection as a cause of lower abdominal pains among antenatal women and its aetiological microorganism and define the sensitivity pattern to commonly used antibiotics. Study Design . A cross sectional study. Setting . Kenyatta National Hospital, Nairobi, Kenya. Subjects . One hundred and fifty antenatal women. Main Outcome Measures . Overall the prevalence of urinary tract infection, its aetiological causes, and antibiotic sensitivity pattern. Results . The prevalence of UTI among antenatal women presenting with lower abdominal pains in Kenyatta National Hospital was found to be 26.7%. Of the 40 women with positive culture urine, 31 (C77.8%) were also positive on dipstick and 27 (67.5%) were positive on urine microscopy. There is significant correlation between urine dipstick testing, urine microscopy, and positive urine culture in UTI. Dipstick test and urine microscopy test had high sensitivity and specificity in screening for UTI. The predominant bacterial pathogens were Escherichia coli at 40% followed by Staphylococcus spp. at 25% and Klebsiella spp. at 10%. There were also Enterococcus , Enterobacter, and Citrobacter species. The isolated gram-negative bacteria were 100% sensitive to meropenem, imipenem, augmentin, ceftazidime, and levofloxacin and about 81% to cefuroxime. The bacteria showed significant resistance to gentamycin and ampicillin of up to 80%. The isolated gram-positive bacteria were 100% sensitive to augmentin, cefuroxime, ceftriaxone, ceftazidime, meropenem, and imipenem but showed significant resistance to levofloxacin, gentamycin, nitrofurantoin, and ampicillin of between 20% and 80%.