More Than 12 % Polarization and 20 Minute Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water

• Published in: Angewandte Chemie International Edition 2018-08, Vol.57 (33), p.10692-10696
• Main Authors: McCormick, Jeffrey, Korchak, Sergey, Mamone, Salvatore, Ertas, Yavuz N., Liu, Zhiyu, Verlinsky, Luke, Wagner, Shawn, Glöggler, Stefan, Bouchard, Louis‐S.
• Format: Article
• Language: English
• Subjects: Biocompatibility; Catalysis; Catalysts; Choline; Contrast agents; Deuteration; heterogeneous catalysis; Hyperpolarization; In vivo methods and tests; Induced polarization; Magnetic resonance imaging; parahydrogen-induced polarization; Polarization; polarization transfer; Quaternary ammonium salts; Relaxation time; Rhodium; rhodium nanoparticles; Structure-function relationships
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201804185

Hyperpolarization techniques are key to extending the capabilities of MRI for the investigation of structural, functional and metabolic processes in vivo. Recent heterogeneous catalyst development has produced high polarization in water using parahydrogen with biologically relevant contrast agents. A heterogeneous ligand‐stabilized Rh catalyst is introduced that is capable of achieving 15N polarization of 12.2±2.7 % by hydrogenation of neurine into a choline derivative. This is the highest 15N polarization of any parahydrogen method in water to date. Notably, this was performed using a deuterated quaternary amine with an exceptionally long spin‐lattice relaxation time (T1) of 21.0±0.4 min. These results open the door to the possibility of 15N in vivo imaging using nontoxic similar model systems because of the biocompatibility of the production media and the stability of the heterogeneous catalyst using parahydrogen‐induced polarization (PHIP) as the hyperpolarization method. High polarization in water: By using a heterogeneous nanoparticle catalyst and an efficient pulse sequence, the observation of 15N nuclear‐spin polarization in excess of 12 % in a choline derivative are demonstrated in water by parahydrogen‐induced polarization (PHIP). A very long T1 relaxation of over 20 min is also observed, as well as versatility with previous PHIP methods and target nuclei (13C), opening new applications for medical MRI.