Chemical sensing by nonequilibrium cooperative receptors

Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process...

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Bibliographic Details
Published in:arXiv.org 2013-07
Main Authors: Skoge, Monica, Naqvi, Sahin, Meir, Yigal, Wingreen, Ned S
Format: Article
Language:English
Subjects:
Energy dissipation
High gain
Organic chemistry
Receptors
Tradeoffs
Online Access:Get full text
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Summary:Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize SNR, revealing a new design principle for biological sensors.
ISSN:2331-8422
DOI:10.48550/arxiv.1307.2930