To the problem of cross-bridge tension in steady muscle shortening and lengthening

Despite the great success of the Huxley sliding filament model proposed half a century ago for actin-myosin linkages (cross-bridges), it fails to explain the force-velocity behavior of stretching skeletal muscles. Huxley's two-state kinetic equation for cross-bridge proportions is therefore rec...

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Bibliographic Details
Published in:arXiv.org 2009-09
Main Author: Kokshenev, Valery B
Format: Article
Language:English
Subjects:
Bridge failure
Kinetic equations
Mathematical models
Muscles
Myosin
Parameters
Statistical thermodynamics
Online Access:Get full text
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Summary:Despite the great success of the Huxley sliding filament model proposed half a century ago for actin-myosin linkages (cross-bridges), it fails to explain the force-velocity behavior of stretching skeletal muscles. Huxley's two-state kinetic equation for cross-bridge proportions is therefore reconsidered and a new solution to the problem of steady muscle eccentric and concentric contractions is reported. When the second law of statistical thermodynamics is applied to cross-bridge proportions, the weakly bound states appear to be correlated to the strongly bound states via structural and kinetic intrinsic muscle characteristics. The explicit force-velocity curve fits the empirical tension-velocity data on frog muscle shortening using only one adjustable parameter, while the Huxley model employed four parameters.
ISSN:2331-8422