4‐Dimethylaminopyridine‐Catalyzed Regioselective [3+2] Cycloaddition of Isatin‐Derived Morita−Baylis−Hillman Adducts with Azo Esters: A Simple Protocol to Access 3‐Spiropyrazole‐2‐oxindoles

An efficient and regioselective 4‐dimethylaminopyridine catalyzed [3+2] cycloaddition of isatin‐derived Morita−Baylis−Hillman adducts with azo esters was developed for the construction of 3‐spiropyrazole‐2‐oxindoles. This protocol generated the desired spiropyrazoles in good to excellent yields with...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2018-08, Vol.360 (16), p.3176-3180
Main Authors: Ren, Yue, Meng, Ling‐Guo, Peng, Tao, Zhu, Lijuan, Wang, Lei
Format: Article
Language:English
Subjects:
3-spiropyrazole-2-oxindoles
Adducts
azo esters
catalyst
Cycloaddition
DMAP
Esters
Functional groups
Regioselectivity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient and regioselective 4‐dimethylaminopyridine catalyzed [3+2] cycloaddition of isatin‐derived Morita−Baylis−Hillman adducts with azo esters was developed for the construction of 3‐spiropyrazole‐2‐oxindoles. This protocol generated the desired spiropyrazoles in good to excellent yields with good functional group compatibility under mild reaction conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800552