Modulation of Human Brain Mu Opoid Receptor Binding during Capsaicin-Induced Pain Measured by PET

There is clear evidence that the endogenous opioid system plays a role in human pain processing and modulation (1,2,3) but the precise physiological role of regional brain opioid function in regulating pain intensity remains uncertain. PET offers a unique opportunity to investigate the dynamic chang...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 1998-05, Vol.7 (4), p.A53-A53
Main Authors: Oropeza, M., Fuchs, P.N., Bencherif, B., Li, S.T., Ravert, H., Musachio, J., Mathews, B., Campbell, J.N., Dannals, B., Frost, J.J.
Format: Article
Language:English
Subjects:
Brain
Capsaicin
Hypotheses
Narcotics
Pain
Peptides
Positron emission tomography
Citations: Items that this one cites
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Summary:There is clear evidence that the endogenous opioid system plays a role in human pain processing and modulation (1,2,3) but the precise physiological role of regional brain opioid function in regulating pain intensity remains uncertain. PET offers a unique opportunity to investigate the dynamic changes produced by synaptic activity within specific brain structures during defined states of human brain function, but the ability of painful stimuli to induce changes in opioid receptor binding has not yet been demonstrated.
ISSN:1053-8119
1095-9572
DOI:10.1016/S1053-8119(18)31922-0