Do soy isoflavones cause endometrial hyperplasia?

For many years, hormone replacement therapy (HRT) was considered the gold standard for the symptomatic treatment of menopause. Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been s...

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Bibliographic Details
Published in:Nutrition reviews 2005-11, Vol.63 (11), p.392-397
Main Author: Mahady, G.B
Format: Article
Language:English
Subjects:
adverse effects
animal models
Animals
Biological and medical sciences
Cancer
endometrial hyperplasia
Endometrial Hyperplasia - chemically induced
endometrium
epidemiological studies
estrogenic properties
Feeding. Feeding behavior
Female
flavonoids
Fundamental and applied biological sciences. Psychology
Glycine max - adverse effects
Hormone replacement therapy
Hormones. Endocrine system
human health
Humans
hyperplasia
isoflavones
Isoflavones - administration & dosage
Isoflavones - adverse effects
Macaca
Medical sciences
Medical treatment
Menopause
Menopause - physiology
Mice
Middle Aged
Pharmacology. Drug treatments
Plant Extracts - administration & dosage
Plant Extracts - adverse effects
Postmenopause - physiology
soy
soy intake
Soy products
soybean products
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Women
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Description
Summary:For many years, hormone replacement therapy (HRT) was considered the gold standard for the symptomatic treatment of menopause. Clinical trials have found that HRT reduces the symptoms of hot flashes and sweating, while also decreasing vaginal dryness and urinary tract infections. HRT has also been shown to be protective against colon cancer (37%) and hip fractures (34%). However, recent findings from the Women's Health Initiative (WHI) have revealed that long-term HRT may actually lead to an increase in heart disease (29%), breast cancer (26%) and other adverse events, such as stroke (41%). Consequently, many women in the United States and abroad are actively looking for alternative treatments for menopause, including botanical dietary supplements.
ISSN:0029-6643
1753-4887
DOI:10.1111/j.1753-4887.2005.tb00376.x