Effects of the IL-23–IL-17 pathway on bone in spondyloarthritis

Over the past several years, a pathophysiological role for the IL-23–IL-17 pathway in human disease has been defined. A subset of rheumatic diseases, including psoriatic arthritis (PsA) and ankylosing spondylitis (AS), are now acknowledged to be triggered by dysregulated IL-23–IL-17 pathway activati...

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Bibliographic Details
Published in:Nature reviews. Rheumatology 2018-11, Vol.14 (11), p.631-640
Main Authors: Gravallese, Ellen M., Schett, Georg
Format: Article
Language:English
Subjects:
631/136/815
692/699/1670/2766/1827
692/699/1670/2766/1900
Animals
Ankylosing spondylitis
Arthritis
Arthritis, Psoriatic - genetics
Arthritis, Psoriatic - immunology
Bone growth
Bone loss
Care and treatment
Clinical trials
Development and progression
Gene expression
Genetic aspects
Genetic Predisposition to Disease
Health aspects
Humans
Inflammatory diseases
Interleukin 17
Interleukin 23
Interleukin-17 - genetics
Interleukin-17 - metabolism
Interleukin-23 - genetics
Interleukin-23 - metabolism
Interleukins
Lymphocytes T
Lymphoid cells
Medicine
Medicine & Public Health
Mice
Microenvironments
Myeloid cells
Osteoblastogenesis
Osteoblasts
Osteoclastogenesis
Osteoclasts
Osteogenesis
Phenotypes
Psoriatic arthritis
Review Article
Rheumatic diseases
Rheumatology
Signal Transduction
Spondylarthritis - genetics
Spondylarthritis - immunology
Spondylitis
TRANCE protein
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