Transferrin-bearing maghemite nano-constructs for biomedical applications

Superparamagnetic nanoparticles (NPs) are widely used in biomedicine for hyperthermia and magnetic resonance imagery. Targeting them to specific cancerous cells is, therefore, of a great value for therapy and diagnostic. Transferrin and its receptor constitute the major iron-acquisition system in hu...

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Bibliographic Details
Published in:Journal of applied physics 2015-05, Vol.117 (17), p.17
Main Authors: Piraux, H., Hai, J., Gaudisson, T., Ammar, S., Gazeau, F., El Hage Chahine, J. M., Hémadi, M.
Format: Article
Language:English
Subjects:
Aminopropyltriethoxysilane
Biomedical materials
Brain
Diagnostic systems
Hyperthermia
Imagery
Magnetic properties
Magnetic resonance
Nanoparticles
Stability analysis
Transferrin
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Summary:Superparamagnetic nanoparticles (NPs) are widely used in biomedicine for hyperthermia and magnetic resonance imagery. Targeting them to specific cancerous cells is, therefore, of a great value for therapy and diagnostic. Transferrin and its receptor constitute the major iron-acquisition system in human. The former crosses the plasma membrane within a few minutes by receptor-mediated endocytosis. Thus, transferrin can be a valuable vector for the delivery of NPs to specific cells and across the blood brain barrier. For such a purpose, three different sizes of maghemite NPs (5, 10, and 15 nm) were synthesized by the polyol method, coated with 3-aminopropyltriethoxysilane, and coupled to transferrin by amide bonds. The number of transferrins per nanoparticle was determined. Raw nanoparticles and the “transferrin-nanoparticle” constructs were characterized. The magnetic properties and the colloidal stability of raw NPs and transferrin-NP constructs were measured and analyzed in relation to their inorganic core size variation. They all proved to be good candidates for nanoparticle targeting for biomedical application.
ISSN:0021-8979
1089-7550
DOI:10.1063/1.4919258