Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants

To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. Prospective population based cohort study. UK Biobank Study, UK. 306 473 men and women, aged 40-73 years, recruited between 2006 and 2010. Hazard ratios for a first stroke, estimated using Cox regressi...

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Bibliographic Details
Published in:BMJ. British medical journal (Clinical research ed.) 2018-10, Vol.363 (8173), p.k4168
Main Authors: Rutten-Jacobs, Loes CA, Larsson, Susanna C, Malik, Rainer, Rannikmäe, Kristiina, Sudlow, Cathie L, Dichgans, Martin, Markus, Hugh S, Traylor, Matthew
Format: Article
Language:English
Subjects:
Adult
Aged
Body mass index
Cardiovascular disease
Cerebral Hemorrhage - epidemiology
Cohort analysis
Coronary vessels
Exercise - physiology
Family medical history
Female
Gender differences
Genetic Predisposition to Disease
Genomes
Haplotypes
Health behavior
Health risk assessment
Healthy Lifestyle
Heart attacks
Humans
Incidence
Lifestyles
Male
Middle Aged
Multifactorial Inheritance - genetics
Myocardial Infarction - epidemiology
Patient Compliance
Polymorphism, Single Nucleotide - genetics
Population studies
Principal components analysis
Prospective Studies
Risk Factors
Single-nucleotide polymorphism
Stroke
Stroke - epidemiology
Stroke - genetics
Subarachnoid hemorrhage
Subarachnoid Hemorrhage - epidemiology
United Kingdom
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