Both dietary fish-oil supplementation and aspirin fail to inhibit atherosclerosis in long-term vein bypass grafts in moderately hypercholesterolemic nonhuman primates

Aortocoronary vein bypass grafts are vulnerable to late atherosclerotic occlusion. Conventional platelet inhibitor therapy provides early but not persistent protection against graft failure. Evidence suggests that consumption of marine foods may reduce cardiovascular disease, possibly because of the...

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Published in:Circulation (New York, N.Y.) N.Y.), 1997-08, Vol.96 (3), p.968-974
Main Authors: BOERBOOM, L. E, OLINGER, G. N, HOSSEIN ALMASSI, G, SKRINSKA, V. A
Format: Article
Language:English
Subjects:
Animals
Arteriosclerosis - etiology
Arteriosclerosis - prevention & control
Aspirin - pharmacology
Biological and medical sciences
Cardiovascular system
Coronary Artery Bypass
Dietary Fats, Unsaturated - pharmacology
Drug Synergism
Fish Oils - pharmacology
Hypercholesterolemia - blood
Hypercholesterolemia - complications
Macaca fascicularis
Male
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Time Factors
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Summary:Aortocoronary vein bypass grafts are vulnerable to late atherosclerotic occlusion. Conventional platelet inhibitor therapy provides early but not persistent protection against graft failure. Evidence suggests that consumption of marine foods may reduce cardiovascular disease, possibly because of the unique long-chain unsaturated omega-3 fatty acids present in these foods. We hypothesized that dietary fish-oil supplementation would protect against atherosclerosis in vein bypass grafts. Thirty-three moderately hypercholesterolemic cynomolgus macaques were divided into four groups: control, control+aspirin, fish oil, and fish oil+aspirin. Each control group received olive oil as placebo to equalize calorie and fat consumption with that of the fish-oil groups. Both oils were in ethyl ester form, with the fish oil providing 0.88 g/d eicosapentaenoic acid. The aspirin dose was 40 mg/d. Cephalic vein grafts were interposed bilaterally in the carotid arteries and excised for analysis at 4 years. Bleeding time was significantly prolonged in all groups receiving fish oil or aspirin (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.96.3.968