TREM2 — a key player in microglial biology and Alzheimer disease

Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary tangles. Familial AD typically results from mutations in the genes encoding amyloid precursor protein ( APP ), pres...

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Bibliographic Details
Published in:Nature reviews. Neurology 2018-11, Vol.14 (11), p.667-675
Main Authors: Ulland, Tyler K., Colonna, Marco
Format: Article
Language:English
Subjects:
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Alzheimer's disease
Care and treatment
Cell receptors
Development and progression
Genetic aspects
Health aspects
Medicine
Medicine & Public Health
Metabolism
Neurodegeneration
Neurology
Review Article
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