Recovery of Susceptibility Following Audiogenic Seizure in Mice

The rate at which SJL/J mice recover susceptibility following an initial sound-induced seizure was examined. Fewer than 15% of the subjects seized when retested after a 2-min delay, and only 50% reseized after a 10-min delay. The likelihood of a second seizure was enhanced if the initial seizure exh...

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Bibliographic Details
Published in:The Journal of general psychology 1991-07, Vol.118 (3), p.285-290
Main Authors: Reid, Howard M., Muench, Jean L.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Animals
Biological and medical sciences
Ears & hearing
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Infant, Newborn
Medical disorders
Medical sciences
Mice
Models, Neurological
Nervous system (semeiology, syndromes)
Neural Inhibition
Neurology
Refractory Period, Electrophysiological - physiology
Rodents
Seizures - physiopathology
Time Factors
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Description
Summary:The rate at which SJL/J mice recover susceptibility following an initial sound-induced seizure was examined. Fewer than 15% of the subjects seized when retested after a 2-min delay, and only 50% reseized after a 10-min delay. The likelihood of a second seizure was enhanced if the initial seizure exhibited a rapid progression to clonus. During the retest, seizures progressed more slowly than during the initial test, which indicates that recovery was not complete even if a second seizure was induced. Finally, recovery of seizure susceptibility was prevented as long as the subject continued to be exposed to intense auditory stimulation following the initial convulsion, an effect previously noted by Alexander and Kopeloff (1980). The findings are discussed in terms of a recently proposed central inhibitory model of the recovery of audiogenic seizure susceptibility.
ISSN:0022-1309
1940-0888
DOI:10.1080/00221309.1991.9917787