Asymmetric Phosphine‐Catalyzed [4+1] Annulations of o ‐Quinone Methides with MBH Carbonates

Chiral dihydrobenzofuran units are frequently present in molecules with significant biological and pharmaceutical activities. Herein, we present the first enantioselective formal [4+1] annulation of Morita‐Baylis‐Hillman carbonates with o ‐quinone methides ( o ‐QMs) catalyzed by a newly designed chi...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2018-12, Vol.360 (23), p.4475-4479
Main Authors: Zhou, Tao, Xia, Tong, Liu, Zhenli, Liu, Lu, Zhang, Junliang
Format: Article
Language:English
Subjects:
Carbonates
Chemical reactions
Enantiomers
Organic chemistry
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Summary:Chiral dihydrobenzofuran units are frequently present in molecules with significant biological and pharmaceutical activities. Herein, we present the first enantioselective formal [4+1] annulation of Morita‐Baylis‐Hillman carbonates with o ‐quinone methides ( o ‐QMs) catalyzed by a newly designed chiral phosphine catalyst. Under the mild and eco‐friendly conditions, a wide range of polysubstituted dihydrobenzofurans were obtained in good yields with excellent enantioselectivities. magnified image
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201801152