Carpal Tunnel Syndrome. A New Feature in the Natural History of TOS?

Objective: To ascertain whether carpal tunnel syndrome (CTS) in patients affected with toxic oil syndrome (TOS) is associated with conditions and diseases considered risk factors for CTS in the general population and/or with certain clinical manifestations of TOS. Methods: We conducted a case-contro...

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Bibliographic Details
Published in:European journal of epidemiology 2003-01, Vol.18 (10), p.983-993
Main Authors: de Cabo, Eva Estirado, de la Paz, Manuel Posada, Pilar de Andrés Copa, Mar del Mar Plaza Cano, Marisa L. García de Aguinaga, Álvarez, Carmen Suarez, Saro, Beatriz Braun
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body mass index
Carpal tunnel syndrome
Carpal Tunnel Syndrome - chemically induced
Carpal Tunnel Syndrome - epidemiology
Case studies
Case-Control Studies
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Diabetes mellitus
Diabetic neuropathies
Epidemiology
Fatty Acids, Monounsaturated
Female
Females
Food Contamination
Humans
Locomotor Disease
Male
Median Neuropathy - chemically induced
Median Neuropathy - epidemiology
Medical sciences
Nervous system (semeiology, syndromes)
Nervous system diseases
Neurology
Obesity
Odds Ratio
Ovariectomy
Overuse injuries
Peripheral nervous system diseases
Plant Oils - poisoning
Poisoning - epidemiology
Poisoning - physiopathology
Predisposing factors
Rapeseed Oil
Regression analysis
Risk Factors
Spain - epidemiology
Toxic oil syndrome
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Summary:Objective: To ascertain whether carpal tunnel syndrome (CTS) in patients affected with toxic oil syndrome (TOS) is associated with conditions and diseases considered risk factors for CTS in the general population and/or with certain clinical manifestations of TOS. Methods: We conducted a case-control study to compare 89 TOS patients residing in Madrid diagnosed with CTS from 1981 through July 2001 (cases) against 638 TOS patients not affected with CTS (controls). Risk factors for CTS and clinical manifestations of TOS were analyzed. Results: Multivariate logistic regression analysis yielded the following odds ratios (95% confidence interval): 3.32 (1.47-7.50) for TOS-related neuropathy; 2.85 (1.14-7.13) for TOS-related thromboembolic events; 2.63 (1.36-5.06) for female gender; 0.43 (0.24-0.80) for TOS-related scleroderma; 0.26 (0.12-0.59) for smoking; and, in women, 2.53 (1.06-5.70) for fibrositis and 1.84 (1.04-3.20) for miscarriages. Conclusion: Our study findings support the hypothesis that CTS in TOS patients is more linked to certain clinical manifestations of TOS, mainly neuropathy, than to conditions and diseases considered risk factors for CTS in the general population.
ISSN:0393-2990
1573-7284
DOI:10.1023/A:1025899506009