Multimodality treatment of peritoneal carcinomatosis from colorectal cancer : first results of a new german centre for peritoneal surface malignancies

The presence of peritoneal carcinomatosis arising from colorectal cancer is associated with a poor prognosis. It was the purpose of this study to analyze morbidity, mortality, and survival after major cytoreductive surgery and intraperitoneal chemotherapy. Thirty-two patients with peritoneal carcino...

Full description

Saved in:
Bibliographic Details
Published in:International journal of colorectal disease 2007-11, Vol.22 (11), p.1295-1300
Main Authors: PISO, P, DAHIKE, M. H, SCHLITT, H. J, GHALI, N, LESALNIEKS, I, LOSS, M, POPP, F, VON BREITENBUCH, P, AGHA, A, LANG, S. A, KULLMANN, F
Format: Article
Language:English
Subjects:
Abdomen
Adult
Aged
Algorithms
Biological and medical sciences
Clinical Trials as Topic
Colorectal Neoplasms - pathology
Combined Modality Therapy
Female
Gastroenterology. Liver. Pancreas. Abdomen
Germany
Humans
Hyperthermia, Induced
Male
Medical sciences
Middle Aged
Omentum - pathology
Other diseases. Semiology
Peritoneal Neoplasms - secondary
Peritoneal Neoplasms - therapy
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The presence of peritoneal carcinomatosis arising from colorectal cancer is associated with a poor prognosis. It was the purpose of this study to analyze morbidity, mortality, and survival after major cytoreductive surgery and intraperitoneal chemotherapy. Thirty-two patients with peritoneal carcinomatosis were operated between April 2004 and June 2006 with the aim of complete macroscopical cytoreduction. All had a primary colorectal carcinoma. Surgery in these patients was followed by hyperthermic intraperitoneal chemotherapy (HIPEC) consisting of mitomycin C and doxorubicin. Data were analyzed retrospectively. Of all patients, 16 had appendix and 16 non-appendiceal colorectal carcinoma. A macroscopically complete cytoreduction was achieved in 24 patients by parietal and visceral peritonectomy procedures. All resections were combined with HIPEC. Overall morbidity was 34%. Most frequent surgical complications were intestinal obstruction (4/32), enteric fistula (2/32), pancreatitis (2/32), and bile leakage (2/32). One patient presented grade 4 renal toxicity. There was no hospital mortality. The median follow-up was 12 months. The 1-year overall survival rate is 96%. All patients after complete cytoreduction are still alive. Cytoreductive surgery combined with HIPEC is associated with an acceptable morbidity and low mortality. Complete cytoreduction may improve survival, particularly in well-selected patients having a low tumor volume and no extra-abdominal metastases.
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-007-0313-z