Manganese(iii)-mediated selective phosphorylation of enamides: direct synthesis of β-phosphoryl enamides

A simple and direct method for the preparation of β-phosphoryl enamides has been achieved through Mn(iii)-mediated radical oxidative selective phosphorylation of N-styrylamides. The reaction could be efficiently scaled-up and the products could be easily transformed into β-amino phosphonic acid, a b...

Full description

Saved in:
Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2019-01, Vol.6 (2), p.236-240
Main Authors: Dong-Liang, Zhang, Cheng-Kun, Li, Zeng, Run-Sheng, Shoberu, Adedamola, Zou, Jian-Ping
Format: Article
Language:English
Subjects:
Acids
Amino acids
Crystallography
Manganese
Organic chemistry
Phosphorylation
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple and direct method for the preparation of β-phosphoryl enamides has been achieved through Mn(iii)-mediated radical oxidative selective phosphorylation of N-styrylamides. The reaction could be efficiently scaled-up and the products could be easily transformed into β-amino phosphonic acid, a bio-isostere of the corresponding amino acid.
ISSN:2052-4110
2052-4110
DOI:10.1039/c8qo01098f