Characterization of a non‐thermally operated electrosurgical argon plasma source by electron spin resonance spectroscopy

Non‐thermal plasma treatment is one of the promising options for local anti‐neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Primarily, the antiproliferative properties are driven through the generation of reactive oxygen and nitrogen species. In this study, we investigat...

Full description

Saved in:
Bibliographic Details
Published in:Plasma processes and polymers 2019-02, Vol.16 (2), p.n/a
Main Authors: Weiss, Martin, Utz, Raphael, Ackermann, Michael, Taran, Florin‐Andrei, Krämer, Bernhard, Hahn, Markus, Wallwiener, Diethelm, Brucker, Sara, Haupt, Michael, Barz, Jakob, Oehr, Christian
Format: Article
Language:English
Subjects:
Aqueous solutions
Argon
Argon plasma
Electron paramagnetic resonance
Electron spin
electron spin resonance spectroscopy (ESR)
Electrons
free radicals
Heat treatment
high‐frequency electrosurgery
Lesions
non‐thermal plasma
Plasma
plasma treatment
Spectroscopy
Spectrum analysis
Spin resonance
Thermal plasmas
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Non‐thermal plasma treatment is one of the promising options for local anti‐neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Primarily, the antiproliferative properties are driven through the generation of reactive oxygen and nitrogen species. In this study, we investigated the amount and distribution of reactive species generated by a non‐thermally operated electrosurgical argon plasma source using electron spin resonance (ESR) spectroscopy. During the plasma treatment of both, aqueous solution and solid human preputial tissue an increasing amount of different oxygen‐ and carbon‐centered radicals was detected. However, and most probably due to spin trap degradation by the high energy input and the increase of reactive components in aqueous solution, the ESR signal decreased after treatment times exceeding 10 s. Non‐thermally operated electrosurgical argon plasma sources reveal a potent emergence of reactive species and may be suitable for usual cold atmospheric plasma applications in plasma medicine. The vigorous generation of reactive plasma components of these plasma sources, being the main trigger for plasma related cell phenomena, may enable efficient treatment of precancerous and cancerous lesions.
ISSN:1612-8850
1612-8869
DOI:10.1002/ppap.201800150