Fabrication of hydroxyapatite blended cyclic type polylactic acid and poly (ε‐caprolactone) tissue engineering scaffold

The ultimate goal of tissue engineering serves to repair, restore damaged tissue or organ due to accident or disease. In this research, we are aimed at investigating the feasibility of processing cyclic type polylactic acid (PDLLA)/poly(ε‐caprolactone) (PCL)/hydroxyapatite (HA) biomaterial into tiss...

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Bibliographic Details
Published in:International journal of applied ceramic technology 2019-03, Vol.16 (2), p.455-461
Main Authors: Yong, Leng Chuan, Abdul Malek, Nur Farihah, Se Yong, Eh Noum, Yap, Wei Hsum, Nobuyuki, Mase, Yoshitaka, Nakaya
Format: Article
Language:English
Subjects:
3D printing
Biocompatibility
Biodegradable materials
Biomedical materials
biopolymer
Cell adhesion
Cell adhesion & migration
cell biocompatibility
Compression tests
Deformation
Honeycomb construction
Hydroxyapatite
Laser microscopy
Mechanical properties
poly(ε‐caprolactone)
Polycaprolactone
Polylactic acid
Porous materials
Robot control
Scaffolds
Surgical implants
Three dimensional printing
Tissue engineering
tissue engineering scaffold
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Summary:The ultimate goal of tissue engineering serves to repair, restore damaged tissue or organ due to accident or disease. In this research, we are aimed at investigating the feasibility of processing cyclic type polylactic acid (PDLLA)/poly(ε‐caprolactone) (PCL)/hydroxyapatite (HA) biomaterial into tissue engineering scaffold (TES) with variable mechanical properties, well interconnected pore architecture, and controlled hydrophilicity. For this, an in‐house built bone scaffold 3D printing (BS3P) system was applied to two biomaterials, namely PDLLA‐PCL and HA‐PCL. These two biomaterials were produced by optimizing the robotic control system. Morphological investigation by scanning electron microscope (SEM) revealed both TES formed by new materials able to show honeycomb‐like architectures, excellent fusion at the filament junctions, high uniformity, complete interconnectivity, and controlled channel characteristics of the TES. Compression tests align with the typical behavior of a porous material undergoing deformation. In vitro cell culture study and confocal laser microscopy (CLM) showed enhanced cell adhesion, proliferation, and extracellular matrix (ECM) formation. The results demonstrated the eligibility of the BS3P system to produce TES, and the suitability of the new biomaterial scaffolds in enhancing cell biocompatibility.
ISSN:1546-542X
1744-7402
DOI:10.1111/ijac.13115