Na+,K+-ATPase activity in an animal model of mania

We evaluated Na + ,K + -ATPase activity in hippocampus of rats submitted to an animal model of mania which included the use of lithium and valproate. In the acute treatment, amphetamine or saline was administered to rats for 14 days, between day 8 and 14, rats were treated with lithium, valproate or...

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Bibliographic Details
Published in:Journal of Neural Transmission 2009-04, Vol.116 (4), p.431-436
Main Authors: Zugno, Alexandra I., Valvassori, Samira S., Scherer, Emilene B. S., Mattos, Cristiane, Matté, Cristiane, Ferreira, Camila L., Rezin, Gislaine T., Wyse, Angela T. S., Quevedo, João, Streck, Emilio L.
Format: Article
Language:English
Subjects:
Amphetamine
Analysis of Variance
Animals
Antimanic Agents - therapeutic use
Basic Neurosciences
Bipolar Disorder - chemically induced
Bipolar Disorder - drug therapy
Bipolar Disorder - enzymology
Disease Models, Animal
Genetics and Immunology - Original Article
Hippocampus - enzymology
Lithium Compounds - therapeutic use
Male
Medicine
Medicine & Public Health
Motor Activity - drug effects
Neurology
Neurosciences
Psychiatry
Rats
Rats, Wistar
Sodium-Potassium-Exchanging ATPase - metabolism
Valproic Acid - therapeutic use
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Summary:We evaluated Na + ,K + -ATPase activity in hippocampus of rats submitted to an animal model of mania which included the use of lithium and valproate. In the acute treatment, amphetamine or saline was administered to rats for 14 days, between day 8 and 14, rats were treated with lithium, valproate or saline. In the maintenance treatment, rats were treated with lithium, valproate or saline, between day 8 and 14, amphetamine or saline were administered. Locomotor activity was assessed by open field test and Na + ,K + -ATPase activity was measured. Our results showed that mood stabilizers reversed and prevented amphetamine-induced behavioral effects. Moreover, amphetamine (acute treatment) increased Na + ,K + -ATPase activity, and administration of lithium or valproate reversed this effect. In the maintenance treatment, amphetamine increased Na + ,K + -ATPase activity in saline-pretreated rats. Amphetamine administration in lithium- or valproate-pretreated animals did not alter Na + ,K + -ATPase activity. The findings suggest that amphetamine-induced hyperactivity may be associated with an increase in Na + ,K + -ATPase.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-009-0198-9