Vascular and Epidermal Effects of Fibroblast Growth Factor on Irradiated and Nonirradiated Skin Flaps

Head and neck cancer surgeons are often faced with the challenge of managing previously irradiated soft tissue that has poor vascularity and slower epithelialization. This study investigates the effect of supplemental basic fibroblast growth factor (bFGF) on flap vascularity, tissue oxygenation, and...

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Bibliographic Details
Published in:Annals of otology, rhinology & laryngology rhinology & laryngology, 2000-07, Vol.109 (7), p.667-675
Main Authors: Hom, David B., Simplot, Tim C., Manivel, J. Carlos, Pernell, Kerri J., Song, Chang W.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dermatologic Surgical Procedures
Epidermis - cytology
Fibroblast Growth Factor 2 - pharmacology
Male
Medical sciences
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Oxygen - analysis
Radiation Dosage
Skin - metabolism
Skin - radiation effects
Surgical Flaps - blood supply
Surgical Flaps - pathology
Swine
Tumors
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Summary:Head and neck cancer surgeons are often faced with the challenge of managing previously irradiated soft tissue that has poor vascularity and slower epithelialization. This study investigates the effect of supplemental basic fibroblast growth factor (bFGF) on flap vascularity, tissue oxygenation, and epidermal regeneration in nonirradiated (n = 40) and irradiated porcine skin flaps (n = 40). Supplemental bFGF increased vascularity in nonirradiated flaps by 80% (p = .005), with a trend to a higher tissue oxygen level by day 14. The irradiated bFGF-treated flaps did not show increased vascularity or higher tissue oxygen levels 2 weeks after surgery. However, in both irradiated and nonirradiated groups, epidermal regeneration increased by greater than 70% with supplemental bFGF (p lt; .002). The results of this study suggest that supplemental bFGF can increase tissue vascularity in nonirradiated tissues and epidermal regeneration in both nonirradiated and irradiated conditions.
ISSN:0003-4894
1943-572X
DOI:10.1177/000348940010900710