Diurnal variation and age differences in the biochemical markers of bone turnover in horses

Biochemical markers of bone turnover provide sensitive, rapid, and noninvasive monitoring of bone resorption and formation. Serum concentrations of osteocalcin (OC) reflect rates of bone formation, and urinary concentrations of the pyridinium crosslinks pyridinoline (Pyd) and deoxypyridinoline (Dpd)...

Full description

Saved in:
Bibliographic Details
Published in:Journal of animal science 1999-01, Vol.77 (1), p.75-83
Main Authors: Black, A, Schoknecht, P. A, Ralston, S. L, Shapses, S. A
Format: Article
Language:English
Subjects:
Aging - blood
Aging - physiology
Amino Acids - urine
Animals
Biochemistry
Biological and medical sciences
Biomarkers
Bone Remodeling
Bones
Circadian Rhythm
Fundamental and applied biological sciences. Psychology
Horses
Horses - physiology
Hydrocortisone - blood
Male
Osteocalcin - blood
Skeleton and joints
Vertebrates: osteoarticular system, musculoskeletal system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biochemical markers of bone turnover provide sensitive, rapid, and noninvasive monitoring of bone resorption and formation. Serum concentrations of osteocalcin (OC) reflect rates of bone formation, and urinary concentrations of the pyridinium crosslinks pyridinoline (Pyd) and deoxypyridinoline (Dpd) are specific and sensitive markers of bone resorption. These markers are age-dependent and are used to detect and monitor changes in the rates of bone turnover in a variety of orthopedic diseases in humans and may prove to have similar application in horses. This study examined age differences and diurnal variation in OC, Pyd, and Dpd in eight adult geldings and seven weanling colts. Blood and urine were collected at regular intervals over 24 h. Serum OC and cortisol, and urinary Pyd and Dpd were analyzed. Mean 24-h concentrations of cortisol and all three markers were higher (P.17) owing to greater variability between individuals. Cortisol secretion varied (P
ISSN:0021-8812
1525-3163
0021-8812
DOI:10.2527/1999.77175x