Methylcelluloses end-functionalized with peptides as thermoresponsive supramolecular hydrogelators

This paper describes the synthesis of methylcelluloses end-functionalized with peptides and an investigation into their functions. We found that aqueous solutions of methylcellulose end-functionalized not only with carbohydrates but also with peptide segments, such as di(arginine) and di(glutamic ac...

Full description

Saved in:
Bibliographic Details
Published in:Cellulose (London) 2019-01, Vol.26 (1), p.355-382
Main Authors: Suhara, Ryo, Yamagami, Mao, Kamitakahara, Hiroshi, Yoshinaga, Arata, Tanaka, Yoshimasa, Takano, Toshiyuki
Format: Article
Language:English
Subjects:
Aqueous solutions
Bioorganic Chemistry
Body temperature
Carbohydrates
Ceramics
Chemical synthesis
Chemistry
Chemistry and Materials Science
Composites
Drug delivery systems
Glass
Glutamic acid
Human behavior
Hydrogels
Ionic interactions
Natural Materials
Organic Chemistry
Original Paper
Peptides
Physical Chemistry
Polymer Sciences
Segments
Sustainable Development
Thermodynamic properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper describes the synthesis of methylcelluloses end-functionalized with peptides and an investigation into their functions. We found that aqueous solutions of methylcellulose end-functionalized not only with carbohydrates but also with peptide segments, such as di(arginine) and di(glutamic acid), behave as thermoresponsive supramolecular hydrogelators at human-body temperature. The slow drug release from thermoresponsive hydrogels of methylcelluloses end-functionalized with peptides is attributed to ionic interactions between model drugs and peptide segments in these hydrogels. Reactions of methylated cellobiose with di(arginine) and di(glutamic acid) were used to determine optimum reaction conditions for the synthesis of methylcelluloses end-functionalized with these peptide residues). The surface activities, zeta potentials, thermal properties, hydrogelation behavior, and cytotoxicities of these peptide-functionalized methylcelluloses are also discussed. Graphical abstract
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-018-2027-5