Enantioselective electrophilic fluorination of α-aryl-tetralones using a preparation of N-fluoroammonium salts of cinchonine

To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. [Display omitted] The enantioselective electrophilic fluorination of α-aryl-tetralones is promoted by cinchonine/selectfluor combinations. This strategy allow...

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Bibliographic Details
Published in:Journal of fluorine chemistry 2019-01, Vol.217, p.72-79
Main Authors: Souza, Luana G., de O. Domingos, Jorge L., de A. Fernandes, Talita, Renno, Magdalena N., Sansano, Jose M., Najera, Carmen, Costa, Paulo R.R.
Format: Article
Language:English
Subjects:
Aromatic compounds
Cinchona alkaloid
Enantiomers
Enantioselective synthesis
Fluorination
Salts
α-Tetralone
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Summary:To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. [Display omitted] The enantioselective electrophilic fluorination of α-aryl-tetralones is promoted by cinchonine/selectfluor combinations. This strategy allows a facile synthesis of the corresponding 2-fluoro-2-aryl-1-tetralones with excellent yields (up to >98%) and moderate to good enantioselectivity (up to74%).
ISSN:0022-1139
1873-3328
DOI:10.1016/j.jfluchem.2018.11.007