Drug Resistant Tuberculosis: Pattern Seen among Patients Visiting Mayo Hospital, Lahore

Background: Multi drug resistant tuberculosis (MDR-TB) has become a challenge in management of TB. Especially with emergence of drug resistance (DR) over the last decade, it has created ambiguity among healthcare professionals treating this disease and anxiety among patients suffering from drug resi...

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Bibliographic Details
Published in:Pakistan journal of medical research 2018-12, Vol.57 (4), p.132-137
Main Authors: Iqbal, Rizwan, Munir, Muhammad Kashif, Rehman, Sana, Saeed, Saqib
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antitubercular agents
Drug resistance
Drug therapy
HIV
Hospitals
Human immunodeficiency virus
Medical personnel
Microbial drug resistance
Mortality
Multidrug resistant organisms
Negligence
Patients
Tuberculosis
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Summary:Background: Multi drug resistant tuberculosis (MDR-TB) has become a challenge in management of TB. Especially with emergence of drug resistance (DR) over the last decade, it has created ambiguity among healthcare professionals treating this disease and anxiety among patients suffering from drug resistant TB. Thus, increase in drug resistance TB is alarming and reflecting various personal negligence level deficiencies. Continuous monitoring of drug resistance pattern is of great importance. Objective: To see the shifting trends of drug susceptibility patterns among TB patients and to compare the frequencies of drug resistance among primary and acquired TB patients Materials and Methods: This descriptive study was undertaken in Pakistan Health Research Council TB Research Centre and department of pulmonology, King Edward Medical University/Mayo Hospital Lahore during January 2013 to December 2016. Drug susceptibility testing from isolates of 1270 TB patients were carried out by standard drug proportion method. Results: Drug susceptibility testing from isolates of 1270 TB patients including 759 (59.7%) males and 511 (40.3%) females was carried out by standard drug proportion method. Mean age of patients participated in this study was 40.9±17.7. Multi drug resistance was found to be 18.6% among all patients while 36.4% among patients having previous history of treatment. A total of 38.6% TB isolates were resistant to minimum of one first line anti TB drug, of which 2.4% isolates were resistant to all the four first line ATT drugs. Highest MDR TB of 25.7% was reported in 2016. Conclusion: Monitoring of drug susceptibility testing among new and previously treated TB cases is necessary in developing countries for better understanding of disease pattern to provide prompt and appropriate treatment.
ISSN:0030-9842