Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

Optical fibers are widely used in bioimaging systems as flexible endoscopes capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique which allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), paving the way for combing MRI...

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Bibliographic Details
Published in:arXiv.org 2019-03
Main Authors: Noskov, R E, Zanishevskaya, A A, Shuvalov, A A, German, S V, Inozemtseva, O A, Kochergin, T P, Lazareva, E N, Tuchin, V V, Ginzburg, P, Skibina, J S, Gorin, D A
Format: Article
Language:English
Subjects:
Endoscopes
Magnetic resonance imaging
Magnetite
Medical imaging
Nanocomposites
Nanoparticles
NMR
Nuclear magnetic resonance
Optical fibers
Polyelectrolytes
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Summary:Optical fibers are widely used in bioimaging systems as flexible endoscopes capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique which allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), paving the way for combing MRI and optical bioimaging. Our approach is based on Layer-by-Layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI that opens novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo.
ISSN:2331-8422
DOI:10.48550/arxiv.1903.03376