Reationary ability of 3, 5-Dibromo-N-Phenylanthranilic acids Derivatives

• Published in: Research journal of pharmacy and technology 2018-09, Vol.11 (9), p.3947-3949
• Main Authors: Alferova, Diana. A., Svechnikova, Elena N., Suleiman, Marharyta M., Gritsenko, Ivan S., Kazakov, Gennadiy P., Popova, Natalya V., Kiz, Olga V., Yaremenko, Vitaliy D.
• Format: Article
• Language: English
• Subjects: Acids; Chemistry; Pharmaceutical sciences; Pharmacy; Solvents
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2018.00725.4

The study of the acid-base properties of substituted N-phenylanthranilic acid is the important since, because it will allow the design of medicinal substances of this series with already known predictive properties. [...]we have been studiedthe reactivity of 3,5-dibromo-N-phenylanthranilic acids has been studied. The products of these compounds' cyclizationacridinesare used not only as medicines but also as analytical reagents. [...]the study of reactivity of 3,5-dibromo-N-phenylanthranylic acids and their derivatives is of considerable scientific and practical interest, as it allows them to optimize the synthesis and to predict pharmacological activity. The process is describedin the equation (Scheme 1): Data in the Table 1 reveal that 3,5-dibromo-substitutes of N-phenylanthranilic acids (1-11) are rather weak acids which avidity depends on the structure and position of substitutes in non-anthranilic fragment of a molecule.Injection of electron-accepting substitutes(- NO2,-Cl,-Br) enhances the ionization of compounds due to greater stabilization of anions.