Reactive oxygen species in colorectal cancer: The therapeutic impact and its potential roles in tumor progression via perturbation of cellular and physiological dysregulated pathways

Reactive oxygen species (ROS) are produced by mitochondria during metabolism. In physiological states, the production of ROS and their elimination by antioxidants are kept in balance. However, in pathological states, elevated levels of ROS interact with susceptible cellular target compounds includin...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-07, Vol.234 (7), p.10072-10079
Main Authors: Moradi‐Marjaneh, Reyhaneh, Hassanian, Seyed Mahdi, Mehramiz, Mehraneh, Rezayi, Majid, Ferns, Gordon A., Khazaei, Majid, Avan, Amir
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Cancer
Carcinogenesis
Carcinogenesis - metabolism
Carcinogenesis - pathology
Carcinogens
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Deoxyribonucleic acid
Deregulation
Disease Progression
DNA
Homeostasis
Humans
Lipids
Metabolism
Mitochondria
Oxidation-Reduction
Oxidative Stress - physiology
Perturbation
Physiology
progression
Proteins
Reactive oxygen species
Reactive Oxygen Species - metabolism
Signal Transduction - physiology
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Summary:Reactive oxygen species (ROS) are produced by mitochondria during metabolism. In physiological states, the production of ROS and their elimination by antioxidants are kept in balance. However, in pathological states, elevated levels of ROS interact with susceptible cellular target compounds including lipids, proteins, and DNA and deregulate oncogenic signaling pathways that are involved in colorectal cancer (CRC) carcinogenesis. Although antioxidant compounds have been successfully used in the treatment of CRC as prevention approaches, they have also been shown in some cases to promote disease progression. In this review, we focus on the role of ROS in gastrointestinal homeostasis, CRC progression, diagnosis, and therapy with particular emphasis on ROS‐stimulated pathways. The role of redox‐sensitive signaling pathways in colorectal cancer progression.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.27881