Radiation-induced tumor after stereotactic radiosurgery and whole brain radiotherapy: case report and literature review

Radiation-induced neoplasms are extremely rare after stereotactic radiosurgery. To date, only 3 cases meet Cahan's criteria in the world literature. We present a fourth case of a radiation-induced neoplasm arising after radiosurgery. The patient is a 43-year-old woman who presented with a right...

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Bibliographic Details
Published in:Journal of neuro-oncology 2004-02, Vol.66 (3), p.301-305
Main Authors: MCIVER, Jon I, POLLOCK, Bruce E
Format: Article
Language:English
Subjects:
Adult
Astrocytoma - etiology
Astrocytoma - pathology
Biological and medical sciences
Brain Neoplasms - radiotherapy
Brain Neoplasms - secondary
Cerebellar Neoplasms - etiology
Cerebellar Neoplasms - pathology
Combined Modality Therapy
Cranial Irradiation - adverse effects
Female
Humans
Magnetic Resonance Imaging
Medical sciences
Melanoma - radiotherapy
Melanoma - secondary
Neoplasm Recurrence, Local - radiotherapy
Neoplasms, Radiation-Induced - etiology
Neoplasms, Radiation-Induced - pathology
Neurology
Radiation Dosage
Radiosurgery - adverse effects
Treatment Outcome
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Summary:Radiation-induced neoplasms are extremely rare after stereotactic radiosurgery. To date, only 3 cases meet Cahan's criteria in the world literature. We present a fourth case of a radiation-induced neoplasm arising after radiosurgery. The patient is a 43-year-old woman who presented with a right cerebellar anaplastic astrocytoma 64 months after radiosurgery for metastatic melanoma. Initially, 3 brain metastases involving the inferior right temporal (2 tumors) and right frontal regions were treated. Following radiosurgery, the patient underwent whole brain radiotherapy (37.5 Gy). Twenty-two months later, a second radiosurgical procedure was performed for a recurrent right temporal lobe metastasis. The area of cerebellum where the glioma developed received a maximum dose of 7.7 and 1.5 Gy during the 2 procedures, respectively. Support that radiosurgery contributed to the development of this glioma are the tumor's location and the rarity of adult cerebellar astrocytomas. The risk of radiation-induced tumors after radiosurgery is unknown. To better define the incidence of radiation-induced neoplasms after radiosurgery, all potential cases should be presented and discussed in an open, candid fashion.
ISSN:0167-594X
1573-7373
DOI:10.1023/b:neon.0000014497.28981.4b