Serum selenium and pancreatic cancer: a prospective study in the Prostate, Lung, Colorectal and Ovarian Cancer Trial cohort

Purpose Pancreatic cancer(PCa) is one of the most lethal cancers with few known consistent nutrition-related risk factors. Epidemiologic associations between the trace element selenium and PCa are inconsistent. This study examined the association of pre-diagnostic serum selenium with incident PCa. M...

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Bibliographic Details
Published in:Cancer causes & control 2019-05, Vol.30 (5), p.457-464
Main Authors: Chatterjee, Sharmila, Combs, Gerald F., Chattopadhyay, Amit, Stolzenberg-Solomon, Rachael
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Cancer screening
Colorectal cancer
Confidence intervals
Diabetes
Diabetes mellitus
Diagnostic systems
Epidemiology
Health risk assessment
Health risks
Hematology
Lung cancer
Medical screening
Nutrition
Oncology
ORIGINAL PAPER
Ovarian cancer
Pancreatic cancer
Prostate
Public Health
Regression analysis
Risk analysis
Risk factors
Selenium
Smoking
Statistical analysis
Trace elements
Trace elements (nutrients)
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Summary:Purpose Pancreatic cancer(PCa) is one of the most lethal cancers with few known consistent nutrition-related risk factors. Epidemiologic associations between the trace element selenium and PCa are inconsistent. This study examined the association of pre-diagnostic serum selenium with incident PCa. Methods We conducted a nested case–control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Study (PLCO) cohort of men and women 55–70 years old at baseline (1993–2001). In total, 303 PCa cases developed during the 17-year follow-up period (1993–2009). We selected two controls ( n  = 606) for each case who were alive at the time the case was diagnosed who were matched on age, sex, race, and date of blood draw. We used conditional logistic regression analysis to calculate the odds ratio (OR) and 95% confidence intervals (CI) adjusting for smoking status and diabetes mellitus. Results Mean serum selenium concentrations were slightly lower in cases (mean, 95% CI: 139.0 ng/ml, 135.6–138.9) compared to controls (142.5 ng/ml, 140.4–142.4, p = 0.08). Overall, serum selenium was not associated with PCa risk (continuous OR: 0.66; 0.32–1.37). There was no significant interaction by sex, smoking, diabetes, or follow-up time ( p > 0.05). Conclusion Our results do not support the hypothesis that serum selenium is associated with PCa risk.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-019-01147-5