Comparison of Surgisis, Vypro II and TiMesh in contaminated and clean field

• Published in: Hernia : the journal of hernias and abdominal wall surgery 2020-06, Vol.24 (3), p.551-558
• Main Authors: Filipović-Čugura, J., Misir, Z., Hrabač, P., Orešić, T., Vidović, D., Misir, B., Filipović, N., Kirac, I., Mijić, A.
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Animals; Cell proliferation; Coated Materials, Biocompatible - administration & dosage; Coated Materials, Biocompatible - adverse effects; Collagen; Collagen - administration & dosage; Collagen - adverse effects; Contamination; Disease Models, Animal; Fibrosis; Fibrosis - etiology; Foreign-Body Reaction - etiology; Granuloma; Inflammation - etiology; Male; Medicine; Medicine & Public Health; Original Article; Polyglactin 910 - administration & dosage; Polyglactin 910 - adverse effects; Polypropylenes - administration & dosage; Polypropylenes - adverse effects; Prosthesis Implantation - adverse effects; Prosthesis Implantation - methods; Prosthesis-Related Infections - etiology; Prosthesis-Related Infections - microbiology; Rats; Rats, Wistar; Staphylococcal Infections - etiology; Staphylococcus aureus; Surgical Mesh - adverse effects; Titanium - administration & dosage; Titanium - adverse effects; Vascularization
• ISSN: 1265-4906; 1248-9204
• DOI: 10.1007/s10029-019-01949-1

Purpose The study aimed to evaluate the histologic properties and infection resistance of three different mesh materials in a rat model. Methods Each mesh, in both infectious ( n  = 96) and non-infectious groups ( n  = 270), was positioned both in sublay (preperitoneally) and onlay (subcutaneously) locations. Properties of the biological (Surgisis; Cook Surgical), composite, partially resorbing (Vypro II mesh; Ethicon) and non-resorbing (TiMesh; GFE Medizintechnik GmbH) mesh were evaluated and compared. Animals were killed at 7, 21 and 90 days after implantation. The following parameters were evaluated to assess the host response to the mesh material: inflammation, vascularization, fibrosis, collagen formation, Ki67, and a foreign body reaction by granuloma formation (FBG). Results Surgisis mesh produced more pronounced inflammation and cell proliferation, and less intense granuloma formation, as well as fibrosis, compared to the other two groups. When the infected materials were examined, we found signs of local infection to be more often present in Surgisis group of animals. Conclusions In the presence of bacterial contamination, no benefits were observed in the use of the Surgisis prosthesis over the use of TiMesh and Vypro II.